Erythrocyte Anion Exchange Protein 1

A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.

Also Known As:

Band 3 Protein; Anion Exchange Protein 1, Erythrocyte; AE1 Anion Exchanger; AE1 Chloride-Bicarbonate Exchanger; AE1 Cl- HCO3- Exchanger; AE1 Gene Product; Anion Exchanger 1; Antigens, CD233; Band 3 Anion Transport Protein; Band III Protein; CD233 Antigen; CD233 Antigens; Capnophorin; EPB3 Protein; Erythrocyte Anion Exchanger; Erythrocyte Membrane Anion Transport Protein; Erythrocyte Membrane Protein Band 3, Diego Blood Group; Protein Band 3; SLC4A1 Protein; Solute Carrier Family 4 Member 1; Solute Carrier Family 4, Anion Exchanger, Member 1; AE1 Chloride Bicarbonate Exchanger; AE1 Cl HCO3 Exchanger; Anion Exchanger, Erythrocyte; Antigen, CD233; Chloride-Bicarbonate Exchanger, AE1; Exchanger 1, Anion; Protein, EPB3; Anion Transport Protein, Erythrocyte; Erythrocyte Anion Transport Protein; Erythrocyte Membrane Band 3 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
        SLC4A Proteins: 5
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
      - Solute Carrier Proteins: 34
        SLC4A Proteins: 5
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Antiporters: 369
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
      - SLC4A Proteins: 5
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
        SLC4A Proteins: 5
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172
      - Solute Carrier Proteins: 34
        SLC4A Proteins: 5
        Chloride-Bicarbonate Antiporters: 117
        Erythrocyte Anion Exchange Protein 1: 172

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Disease

Drug/Important Bio-Agent (IBA)